Pectin Reduces Blood Cholesterol Level

Pectin Reduces Blood Cholesterol Level Xinhao DAI Introduction Pectin is a complex polysaccharide present in plant cell walls, commonly presents in fruits and vegetables, commercially extracted from pulp waster during fruits juice processing. Pectin can be used as gelling agent in jams, marmalades and reduced sugar versions. It creates thickened textures and a homogenous distribution of fruit pieces. The consumption of pectin by human influences transit rate, nutrient absorption rate, and cholesterol absorption and secretion, so pectin is an important dietary fiber. However, the clinical use of pectin is very rarely mentioned (F Brouns, 2012). The degree of esterification (DE) demonstrates the methyl esters in pectin chains. The pectin with DE>50% are high-methoxyl and forms viscous gels in the stomach at pH 2.2-3.5 (Ralet et al., 1994; Sila et al., 2009); the pectin with DE60%) at low pH; low-methoxyl pectin forms gels with divalent cations (notably Ca 2+) at pH 2.5-6 (sugar addition not required) (Thibault and Ralet, 2008). Cholesterol is an important biological molecule, which function as component of cell membrane structure as well as a precursor for the synthesis of the steroid hormones and bile acids. High concentration of cholesterol in human blood is related with coronary vascular disease, atherosis, stroke and many other diseases. European Food Safety Authority (EFSA) (ESFA, 2010) has published the cholesterol lowing effects of of pectin on glycemia. In general, processing factors like DE, MW, and pectin source (e.g. citrus or apple) may affect the efficacy of pectin (Baker, 1997; Duvetter et al., 2009). Cholesterol lowering in animals Pectin has been reported being able to lower the cholesterol level of blood and liver in various animals, including guinea pigs (Gorinstein et al., 2005), rats (Krzysik et al., 2011), hamsters (Terpstra et al., 2002), chickens (Craig et al., 2006) and rabbits (Ismail et al., 1999). The effect of lowing cholesterol level by nine types of pectin with different molecular composition on 486 male broilers was studies, their serum cholesterol lowing efficacy was ranked as: citrus pectin DE-70 1⠁„4 apple pectin DE-74apple pectin DE-354citrus pectin DE-04low-MW pectin4citrus pectin DE-354cellulose (Craig et al., 2006). The mechanisms of cholesterol lowering in animals mostly are increasing fecal bile acid excretion, reduced plasma triacylglycerol, plasma total cholesterol, hepatic triacylglycerol, cholesterol synthesis and absorption, et al. Some of the mechanisms may be related with humans (F Brouns, 2012). The result of experiments feeding Wistar rats with semipurified diet with psyllium or pectin, cellulose or rice bran supported the hypothesis that the hypocholesterolemic effect of soluble fibers is functioning by increasing synthesis and therefore pool size of bile acids (Hugh B. Matheson, 1995). Another study showed that the hydrophobic amidated pectins significantly modify cholesterol homeostasis in rants and might provide insight of an effective hypochelosterolemic agent. However, the amidation of pectin might reduce its fermentability (M. MAROUNEK, 2007). Overall, pectin influence animal blood cholesterol by affecting cholesterol homeostasis. Cholesterol lowering in humans There are not many clinical studies of pectin cholesterol lowing compared with animal studies. Generally, each gram of pectin lowers LDL cholesterol (LDL-C) by 0.055mmol/L (Brown et al., 1999). A cause-and-effect relationship has been established with 6g pectin in ≠¥ 1 servings for maintenance of normal blood cholesterol concentration (ESFA, 2010). The table 1 summarized the most important studies of pectin lowering cholesterol level before 1988 (Kay Behall, 1986) (Cerda, 1988) Table 1. Pectin Lowering Cholesterol Level Studies Before 1988 A recent crossover study involves hyper-cholesterolemic persons receiving either 15g/day pectin (from citrus or apple, with different DE level) or cellulose with food for 4 weeks. The result showed that (F Brouns, 2012): For relative low-density lipoprotein (LDL) cholesterol (LDL-C), the effect of citrus pectin and apple pectin are the same, while the pectin with higher level of DE level has better hypocholesterolemic effect. Orange pump fiber worked worse than citrus and apple pectin. The pectin with higher molecular weight works better than the pectin with low molecular weight. In the subsequent experiment providing 6g pectin/day for three weeks, citrus DE-70 and high MW pectin DE-70 reduced LDL-C 6-7% compared with control group. The viscous, gelatinizing citrus pectin alter bile acid enterohepatic circulation; enhance cholesterol excretion into stool (Martinez de Prado et al., 1981; Ide and Horii, 1989; Ide et al., 1990; Fernandez et al., 1994; Terpstra et al., 2002). High-viscosity pectin generally diminishes total cholesterol (TC) by 3-7% in humans. Pectin increases gut viscosity, then reduce the re-absorption of bile acids, increase synthesis of bile acids from cholesterol, thereby reduces circulating blood cholesterol (F Brouns, 2012). The high-viscosity pectin might also interfere with the formation of micelles and/or lower the diffusion rate of bile acid and cholesterol-containing micelles through the bolus, consequently reduce the uptake of cholesterol and bile acids. Many study suggested the favourable effect of pectin on lipids(B.R. Sharma, 2006). The source and type of pectin (degree of esterification and molecular weight) affect the effect of lowing cholesterol. In the study by Brouns et al., it is proven that increased DE and MW help promote the efficacy of lowering of human cholesterol level, and even a high dose of pectin with low DE and MW won’t have significant effect. The EFSA pectin cholesterol-lowering claim should require a minimum level of characterization, including DE and MW (F Brouns, 2012). Even though pectin cannot be directly absorbed by human, it can be fermented by the microorganisms in the large intestine and result in the formation of short chain fatty acid, which could be absorbed and metabolized in the colonic mucosa, liver or peripheral tissue (Kay, 1982). Effective doses Experiments indicate that the dose of pectin needed for different people to achieve the lowering of serum cholesterol level is not the same (Grant H. Palmer, June 1966). The intake of 15 grams of pectin per day for three weeks resulted in a mean 13% diminishment of plasma cholesterol levels. A dose of 40 to 50 grams of pectin per day significantly reduced the cholesterol level in both normolipidemic and hyperlipidemic subjects(B.R. Sharma, 2006). In addition with the claim of consume 6g/day pectin to achieve hypochelosterolemic effect, ESFA (2010) also suggest that the consumption of pectin with meals help reduce the blood glucose after meal and the effect can be achieved with at least 10g pectin per meal ((EFSA), 2011). The hypocholesterolemic effect of pectin combined with apple polyphenols has also been reported (EVA N. JENSEN and DRAGSTED, 2009). There might be taste concerns and potential gastrointestinal disturbance if more than 6g pectin/day was ingested (F Brouns, 2012). At least 6 grams of pectin are supposed to be consumed to achieve hypochelesterolemic effect, and this amount is correspond to 7~8 medium-sized apples (EVA N. JENSEN and DRAGSTED, 2009). Some critique suggested that most of the cholesterol lowering effect of pectin is showed in a cholesterol rich, atherogenic diet (A.H.M. Terpstra, 2002). The effect of cholesterol lowing efficiency in regular diet remained quite questionable. Conclusion Viscous pectin can reduce the cholesterol level of animals and human by increasing synthesis and excretion of bile acid and reducing re-absorption of cholesterol. The hypochelosterolemic effect of pectin depends on the dose of pectin, diet composition, and source and physical and chemical property of pectin itself (including viscosity, molecular weight, and degrees of esterification). The effective daily intake of pectin is at least 6g/per according to EFSA, however a minimum level of characterization should be required to achieve the result.

WTO Dispute Settlement Understanding: Case Studies Essay -- World Trade

WTO Dispute Settlement Understanding: Case Studies The World Trade Organization implemented the Dispute Settlement Understanding (DSU) as a means for member countries to settle trade disputes in an orderly process. The process involves an alleged injured country (complainant) filing a request for consultations with the alleged injuring party (respondent). If the consultations do not result in a mutually acceptable outcome, the complainant may request a Panel to hear the case and provide recommendations in accordance with GATT other WTO agreements. If either party disputes the outcome, they may appeal to the Appellate Body (AB), which may uphold or overturn the panel’s decision. Compliance with the recommendations is not compulsory however if a country does not conform to recommendations, the other party may request and impose sanctions on the other party if they are granted (Trebilock, Howe, & Eliason, 2013). Following are summaries of three cases presented before the Dispute Settlement Body. Japan — Measures Affecting the Importation of Apples On March 1, 2002, the United States (US) filed a request for consultations with Japan concerning their Sanitary Phytosanitary (SPS) regulations. At issue was Japans policy of restricting importation of apples from the US to prevent against fire blight bacterium. Since 1994, Japan had required triannual inspection of US apple orchards for fire blight, and banned importation from any orchard showing sign of the blight within a 500-meter perimeter of the orchard. It further required the sanitization of harvested apples with chlorine. The US argued Japan's measures appear to be inconsistent with the obligations of Japan under Article XI of GATT 1994, Articles 2.2, 2.3, 5.1, 5.2, 5.3, 5... ...pan - Measures affecting the importation of apples - Report of the panel. Retrieved from World Trade Organization: https://docs.wto.org/dol2fe/Pages/FE_Search/FE_S_S009-DP.aspx?language=E&CatalogueIdList=14714&CurrentCatalogueIdIndex=0&FullTextSearch= Summary. (2010, February 24). Summary of the dispute to date. Retrieved from World Trade Organization: http://www.wto.org/english/tratop_e/dispu_e/cases_e/ds245_e.htm Trebilock, M., Howe, R., & Eliason, A. (2013). The Regulation of International Trade. New York, NY: Routledge. WT/DS243/8. (2003, July 21). United States - Rules of Origin for Textiles and Apparel Products - Panel Report - Action by the Dispute Settlement Body. Retrieved from World Trade Organization: https://docs.wto.org/dol2fe/Pages/FE_Search/FE_S_S006.aspx?Query=(@Symbol=%20wt/ds243/*)&Language=ENGLISH&Context=FomerScriptedSearch&languageUIChanged=true#

Evaluate factors that influenced the effectiveness of each interaction Essay

In this piece of coursework I will be analysing and evaluating the factors that influence the effectiveness of each interaction in relation to the one to one set at a GP’s for a patient that has really bad back pains and is complaining about how sharp the pain is. I based the one to one interaction on a patient with back problems and they’ve come to the GP’s for something to be given to them. I thought of this because it’s something I went through and I thought it would be nice to let people know what process I went through and how hard it was. The first factor, I thought that influenced the one to one interaction was the patient and doctor taking turns while talking and not interrupting. Turn taking is a major factor that involves our everyday lifestyle and it’s helpful because you know you will get a turn at having your own say. Turn taking helps out a lot especially if you are with younger children or at a GP. For example, the patient came to her doctor and she told her doctor what was wrong with her and how much she’s in pain, the doctor listened to her while she was talking and didn’t ask questions until she finished talking then, the doctor answered all her questions and asked her own questions trying to figure out what was wrong about that patient and what actions will need to be taken for the patient to feel better. Towards the end the doctor referred the patient to her local hospital for an x-ray to see what’s going on. What’s good about turn taking is that everyone listens to each other and you don’t get interrupted also you know you’ll have enough time to talk while others have a chance to think about questions to ask you. The second factor I realised that influenced the one to one interaction was listening. Listening is letting people talk and you concentrating on just what they are saying, listening is a very important communication skill because if you don’t listen you may misunderstand something which may leads you to thinking differently and feeling insecure. Read more: Describe factors which may influence children’s development essay Listening was one factor that influenced the one to one interaction because if one of us didn’t listen while the other person was talking we may have not heard what they were saying or concentrated enough to understand what they were saying which can lead to giving wrong answers which could be a problem to the persons health that’s why when others are talking you always have to listen. For example, in the one to one interaction Emily was my partner and she helped me concentrate listening to  her because little things distract me easily so I had to make sure I listened to her also, we had our script which was used as a prop if we missed out something we carried on listening to each other while looking at what was said to not give the wrong answer. We listened to each other because we knew how important listening is and we were successful at getting through the one to one interaction without not knowing what was going on because we listened to each other. The third factor that also had an influence on the one to one interaction was respect towards each other. Respecting each other shows you give them pride and you are happy about what they are saying or doing also, respect comes from learning to care about people from older ages because we have to respect people to get along with life if we don’t respect then there could be consequences. Respect is very important because we all have to respect everyone no matter what their race, gender, age or features are we have to because we live in a society that moves with respect. For example, if we didn’t respect the army that looks after the country for losing their lives to make the world a much happier place and for us to be safe then that will be a major consequence because what’s the point of those people dying for us if we can’t have a little respect for them. The reason why I thought respect had a influence in the one to one interaction was because if we didnà ¢â‚¬â„¢t respect each other we wouldn’t have been able to understand each other and we wouldn’t have been able to do the doctor and patient script because a doctor always has to respect their patients no matter what happens they have to so does the patient too. An example of this would be, when the patient walked into the room I felt the respect from the patient by the way they answered me and facial expressions. This had a big impact on the interaction because it made it less awkward to talk with the patient and not only was the patient comfortable with asking questions to do with her illness but as a doctor being able to have enough respect from a patient to ask them what areas of the back hurts and being able to have a look at the patients back to check what’s wrong. The last factor that had an influence on the interaction was how professional I was. Being professional can be difficult because if you’ve always been in an environment that’s unprofessional and you don’t know where to use what language that can be an issue. So being professional was key in this interaction because I was a person that had a reputation,  that had power to help people and look after them. If I didn’t act professional the patient could have not taken me serious but I did. The reason why being professional was an influence in the interaction because I realised the more professional you are no matter where you are you will always be looked up to and that’s why I thought it was an influence because it made the patient feel secure with me, it made the patient understand no matter what happens I will always be supporting the patient which would make both of us happy. For example, the minute the patient knocked on the door I dropped everything I was doing and stood up and shock the hand then I made the patient feel welcomed and asked how they were then they started explaining what the problem was and the actions I was doing showed I was professional.

Teaching Strategies And Active Listening Skills - 1019 Words

For a start, I just want to give you some constructive criticism/positive feedback on your SOCW 6392 aging population class. As a student, I have observed your meticulous teaching strategies and active listening skills. I truly appreciate your classroom rules and how you quickly check someone (put them in their place) if they try to step out of line. With a structured class, students are able to stay focused on the course materials and are less likely to get distracted/off topic than when in unstructured/unorganized settings. Parallel to this, you are always actively looking around for other distractions, such as, laptops, cell phones, and other electronic devices. You have displayed your level of professionalism by providing ample amounts of self-disclosure stories about your personal, social work experience (social worker/student/ombudsman) all while keeping twenty-five students (give or take a few) engaged throughout the duration of the lecture. Furthermore, I have noticed/admired your (above average) active listening skills that you have demonstrated throughout the semester. For example, when a student would ask a question and could not fully complete their thought or idea, you would always step in and smoothly articulate their story and connect it to a real life situation or social work field related – and for that, I am thankful for having a professor that is detail oriented and caring. With that being said, let me start off by introducing the highlights of whatShow MoreRelatedEarly Literacy Experiences Set The Foundation Of Learning For Students1354 Words   |  6 Pagesliteracy experiences set the foundation of learning for students. Strengthening literacy skills, particularly language and word recognition are essential to the growth in literacy. The pre-school years can provide rich experiences in early reading. 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